![]() ![]() TCEL-1 NCCN Guidelines Version 2.2015 NCCN Guidelines Index NHL Table of Contents Peripheral T-Cell Lymphomas Discussion The NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN®. Version 2.2015, 03/03/15 © National Comprehensive Cancer Network, Inc. Participation in clinical trials is especially encouraged. Clinical Trials: NCCN believes that the best management of any cancer patient is in a clinical trial. Note: All recommendations are category 2A unless otherwise indicated. EBV and appropriate immunohistochemistry should be performed. dAITL may occasionally present with concurrent DLBCL. cSeemap for prevalence of HTLV-1 by geographic region. bSee Use of Immunophenotyping/Genetic Testing in Differential Diagnosis of Mature B-Celland NK/T- Cell Neoplasms (NHODG-A). T-cell receptor rearrangements alone are not sufficient for diagnosis, as these are often seen with reactive/inflammatory processes. HTLV-1 PCR if serology is indeterminate.ĪMolecular diagnosis for T-cell receptor rearrangements should be done in most circumstances to confirm clonality. Assessment of HTLV-1c serology in at-risk populations.Additional immunohistochemical studies to establish Extranodal NK/T-cell lymphoma, nasal type (See NKTL-1) lymphoma subtype:βγ F1, TCR-C M1, CD279/PD1, CXCL-13.Molecular analysis to detect: antigen receptor gene rearrangements t(2 5) and variants.Primary cutaneous ALCL USEFUL UNDER CERTAIN CIRCUMSTANCES:.Enteropathy-associated T-cell lymphoma (EATL) kappa/lambda, CD45, CD3, CD5, CD19, CD10, CD20, CD30, CD4, CD8, CD7, CD2 TCRαβ TCRγ Subtypesnot included:.ALCL, ALK negative > Cell surface marker analysis by flow cytometry:.Anaplastic large cell lymphoma (ALCL), ALK positive (TCEL-2) or.Angioimmunoblastic T-cell lymphoma (AITL)d See Workup CD4, CD8, CD7, CD56, CD57 CD21, CD23, EBER-ISH, ALK.Peripheral T-cell lymphoma (PTCL), NOS > IHC panel: CD20, CD3, CD10, BCL6, Ki-67, CD5, CD30, CD2,.Adequate immunophenotyping to establish diagnosisa,b.An FNA alone is not sufficient for the initial diagnosis of peripheral T-cell lymphoma.Rebiopsy if consult material is nondiagnostic. Review of all slides with at least one paraffin block representative of the tumor should be done by a hematopathologist with expertise in the diagnosis of PTCL.Peripheral T-Cell Lymphomas NCCN Guidelines Version 2.2015 NCCN Guidelines Index NHL Table of Contents Peripheral T-Cell Lymphomas Discussion ![]() NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines® ) Non-Hodgkin’s Lymphomas Version 2.2015 NCCN Guidelines Index NHL Table of Contents Discussion NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines® ) Non-Hodgkin’S Lymphomas Version 2.2015 ![]()
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